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ey0017.11-13 | Pharmacologic Treatment | ESPEYB17

11.13. Metformin-induced increases in GDF15 are important for suppressing appetite and promoting weight loss

EA Day , RJ Ford , BK Smith , P Mohammadi-Shemirani , MR Morrow , RM Gutgesell , R Lu , AR Raphenya , M Kabiri , AG McArthur , N McInnes , S Hess , G Pare , HC Gerstein , GR Steinberg

To read the full abstract: Nat Metab 2019;1:12021208.Metformin has become a mainstay in the treatment of T2DM in over six decades of clinical use and is today one of the worlds most commonly prescribed drugs. Anti-diabetic properties of metformin rely on an inhibition of hepatic glucose output through AMPK-dependent, but also AMPK-independent effects (reviewed in (1)). Neverthel...

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ey0019.1-2 | Basic Science and Stem Cells | ESPEYB19

1.2. Cis-regulatory architecture of human ESC-derived hypothalamic neuron differentiation aids in variant-to-gene mapping of relevant complex traits

MC Pahl , CA Doege , KM Hodge , SH Littleton , ME Leonard , S Lu , R Rausch , JA Pippin , MC De Rosa , A Basak , JP Bradfield , RK Hammond , K Boehm , RI Berkowitz , C Lasconi , C Su , A Chesi , ME Johnson , AD Wells , BF Voight , RL Leibel , DL Cousminer , SFA Grant

Nat Commun. 2021 Nov 19;12(1):6749. doi: 10.1038/s41467-021-27001-4. PMID: 34799566.Brief Summary: The authors used RNA-seq, ATAC-seq, and promoter-focused Capture C to characterize the genetic architecture during hypothalamic differentiation. This information provides insights into mechanisms by which noncoding GWAS loci are associated with hypothalamic-regulated traits potentially mediat...

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ESPE Yearbook of Paediatric Endocrinology

11.13. Metformin-induced increases in GDF15 are important for suppressing appetite and promoting weight loss

1.2. Cis-regulatory architecture of human ESC-derived hypothalamic neuron differentiation aids in variant-to-gene mapping of relevant complex traits

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